Free Giant Microbe
The STAT diagram was created by Rockland scientists to provide an overview of this important Signaling Pathway. The proteins are linked to the related Rockland antibody products.
To download a PDF version of the STAT Signaling Pathway, click here.
STAT Pathway Description:
Cytokines and growth factors are the major activator of evolutionarily conserved Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. The JAK/STAT signaling pathway transduces signals of more than 50 cytokines and peptide hormones adding plasticity to the response of a cell or tissue. The JAK/STAT pathway influences proliferation, differentiation, migration, apoptosis, and cell survival, depending on the signal, tissue, and cellular context. JAK/STAT signaling is critical for numerous developmental and homeostatic processes, including hematopoiesis, immune cell development, stem cell maintenance, organismal growth, and mammary gland development.
The binding of a ligand to its respective receptor induces autoactivation of the receptor-associated JAK through trans-phosphorylation of tyrosine residues. Active JAKs subsequently phosphorylate critical tyrosines on the cytoplasmic portion of the receptor. These sites serve as docking sites for the SH2-domains of STATs, which get activated through phosphorylation by JAKs upon binding to this site of the receptor. Depending on the cell type and ligand-receptor complex, each JAK activates one or more of the members of the STAT family. Activated STATs separate from the receptor and form stable homo- or heterodimers and translocate to the nucleus where they function as transcription factors by binding to conserved DNA recognition sites.
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