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        NF-κB Signaling Pathway


The NF-κB diagram was created by Rockland scientists to provide an overview of this important Signaling Pathway. The proteins are linked to the related Rockland antibody products.

 

 
Growth FactorPI3K AntibodyAkt/PKB AntibodiesTRAF AntibodyTNF AntibodiesMyD88 AntibodyMyD88 AntibodyIRAK AntibodiesIRAK AntibodiesTOLLIP AntibodyMEK AntibodiesIL-1 AntibodiesTRAF AntibodyPKC AntibodyPKR AntibodyPKC AntibodyIKK-a AntibodyIKK-B AntibodyIKK-y AntibodyIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesIkBs AntibodiesPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificPhospho SpecificNF-kB Rel B AntibodiesNF-kB Rel B AntibodiesNF-kB p52 AntibodyNF-kB p52 AntibodyNF-kB p52 AntibodyNF-kB AntibodyNF-kB p52 AntibodyMEK AntibodiesERK AntibodiesNF-kB p65 AntibodiesNF-kB p65 AntibodiesNF-kB p65 AntibodiesNF-kB p65 AntibodiesNF-kB p65 AntibodiesNF-kB p50 AntibodiesNF-kB p50 AntibodiesNF-kB p50 AntibodiesNF-kB p50 AntibodiesNF-kB p50 AntibodiesNF-kB p50 AntibodiesNF-kB p52 AntibodyUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin AntibodiesUbiquitin Antibodiesk-BRas Antibodyk-BRas AntibodyNF-kB Antibodies

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 NF-κB Pathway Description:

 NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals,ultraviolet irradiation, oxidized LDL and bacterial or viral antigens. More recently, NF-κB has been linked to cancer, inflammatory and auto immune diseases, septic shock, viral infection, and improper immune development.Therefore, NF-κB represents a key target for drug discovery.  

 

 

 

Pathway Key Legend