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        HDAC Specific Antibodies


HDAC-specific Antibodies Overview

 

 

Rockland produces antibodies for epigenetics, including antibodies to histone deacetylases (HDACs). These antibodies are a dominant epigenetic tool and can be used in IF microscopy, immunoprecipitation, IHC and Western Blot analysis.
 

  

 

 

HDAC-button

 

 

Acetylation is a key component in the regulation of gene expression. HDAC enzymes are involved in removing the acetyl group from the histones containing the nucleosome. Other proteins known to be involced in the deacetylation of proteins are SIRTs. In general, hyperacetylation is associated with increased transcriptional activity, whereas decreased levels of acetylation (hypoacetylation) are associated with repression of gene expression. Steady-state levels of acetylation of the core histones result from the balance between the opposing activities of histone acetyltransferases and histone deacetylases (HDACs). In addition to deacetylation of histones, HDACS also are known to deacetylate other proteins including p53 (600-401-H09; 600-401-E04; 200-301-174), a-tubulin, E2F and MyoD. Class I HDACs are found almostexclusively in the nucleus while class II HDACs are able to shuttle in and out of the nucleus in response to certain cellular signals. The table below illustrates which HDAC proteins belong to each class.

 

HDAC Diagram

 


 

 

The Rockland Advantage: HRP Secondary Antibodies

 

Rockland produces HDAC antibodies under rigorous quality control testing. This ensures that the finished product meets or exceeds our high standards for optimum performance in your assays.

 

Rockland offers a variety of choices of HDAC antibodies and buffers to use in histone specific assays including:

 


 

Featured Anti-HDAC Antibodies

 

 

Name Host   Catalog # Applications Size

HDAC-1 Antibody 

Rabbit   600-401-879 ELISA, WB, IHC, IF 100 μg

HDAC4 Antibody 

Rabbit   600-401-J42 ELISA, WB    50 μg

HDAC5 Antibody

Rabbit   600-401-J68 ELISA, WB 100 μg

HDAC6 Antibody 

Rabbit   600-401-J39 ELISA, WB 100 μg

HDAC8 Antibody 

Rabbit   600-401-J72 ELISA, WB 100 μg

HDAC7 Antibody

Rabbit   600-401-J22 ELISA, WB, IF, IHC 100 μg

HDAC9 Antibody (internal)

Rabbit   600-401-J74 ELISA, WB 100 μg

HDAC9 Antibody (N-terminal)

Rabbit   600-401-J73 ELISA, WB 100 μg

HDAC10 Antibody 

Rabbit   600-401-J76 ELISA, WB 100 μg
HDAC11 Antibody
Rabbit    600-401-J17 ELISA, WB, IF, IHC 100 μg

HDAC Assay Buffer 

    MB-068-0020   20 mL

 

 

Epigenetic Button

 

 

 

 

 

 

Reference Rockland Bucket

 

   

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