Anti-NOTCH 1 (Cleaved N terminal) (Human specific) (Rabbit)
Host:
Rabbit Anti-NOTCH 1
Conjugation:
Unconjugated
Background Information:
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form.
Application Notes:
This antibody is reactive with Notch 1 by Western Blotting. A strong response was also detected by ELISA against the immunizing peptide.
General References:
1. Bertrand FE, Eckfeldt CE, Lysholm AS, LeBien TW (2000) Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. Leukemia 12: 2095-2102.
2. Gridley T (2003) Notch signaling and inherited disease syndromes. Hum. Mol. Genet. 12: Suppl 1, R9-R13.