AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation AKT pS473 & AKT pT308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and rac (related to A and C kinases).
Application Notes:
Suitable for Western Blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence Microscopy & ELISA.
General References:
1. Lawlor, M. A. and Alessi, D.R. (2001). PKB/AKT: a key mediator of cell proliferation, survival and insulin responses. J. Cell Science 114:2903-2910.
2. Alessi, D. R. (2001). Discovery of PDK1, one of the missing links in insulin signal transduction. Biochem. Soc. Trans. 29,1 -14.