APC2, also known as Anaphase promoting complex subunit 2, APC2, Cyclosome subunit 2, and ANAPC2.
Application Notes:
This antibody reacts with human APC2 by western blot and immunoprecipitation. The antibody immunoprecipitates in vitro translated protein and protein from overexpressing cell lysates (using HeLa and NIH-3T3, and others).
General References:
1. Jentsch S, Pyrowolakis G. (2000) Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 10(8):335-42.
2. Tang,Z., Li,B., Bharadwaj,R., Zhu,H., Ozkan,E., Hakala,K., Deisenhofer,J. and Yu,H. (2001) APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol. Biol. Cell 12 (12), 3839-3851.
Specific References:
1. Yu H,Peters JM,King RW,Page AM,Hieter P,Kirschner MW, (1998) Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science 279:5354, 1219-1222.
2. Zachariae W,Shevchenko A,Andrews PD,Ciosk R,Galova M,Stark MJ,Mann M,Nasmyth K, (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279:5354, 1216-1219.
