Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation
Application Notes:
This antibody reacts with human and mouse Cul7 by Western Blot and Immunoprecipitation. The antibody immunoprecipitates in vitro translated protein and also immunoprecipitates protein from cell lysates (using HeLa, NIH-3T3, and others).
General References:
1. Jentsch S, Pyrowolakis G. (2000) Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 10(8):335-42
Specific References:
1. Arai,T., Kasper,J.S., Skaar,J.R., Ali,S.H., Takahashi,C. and DeCaprio,J.A. (2003) Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 (17), 9855-9860.
2. Dias,D.C., Dolios,G., Wang,R. and Pan,Z.Q. (2002) CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16601-16606.
