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Apelin (also APJ endogenous ligand) is a secreted hormone expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal glands, endothelium, and human plasma. It is derived from the APLN gene (transcript of 77 amino acids in length) and is an endogenous activator ligand for the G-protein-coupled receptor (GPCR) APJ. Apelin is processed into several different peptides from 12 to 36 amino acids long. The most abundant apelin peptide chains are:
Apelin has been shown to be involved in the regulation of blood pressure, angiogenesis, water and food intake, inflammation, immunodeficiency, and insulin resistance. It further has been shown to inhibit HIV-1 entry in cells co-expressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.
To support cardiovascular function and HIV pathology research Rockland offers a comprehensive group Apelin and Apelin analog peptides to facilitate research.
In combination with peptides for Apelin research, Rockland offers further products that may aid your research.
Recommended related products:
Rockland offers a panel of Apelin peptides that are the highest quality reagents available for cardiovascular, neuroscience and infectious research. Our quality control testing is the most rigorous in the industry. We utilize a high end mass spectrometer (a hybrid quadruple accurate to 10ppm), for all peptides ordered at 85% purity or higher, AND provide tandem MS which confirms the sequence is correct for each peptide.
Rockland Immunochemicals Inc.Limerick, PA 19468E-mail: email@example.comPhone: 800.656.7625