![Histone H4 [Dimethyl Lys20] Immunofluorescence](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-J02-HistoneH4-K20me2-Antibody-1-IF-4x3.jpg "Histone H4 [Dimethyl Lys20] Immunofluorescence")
![Histone H4 [Dimethyl Lys20] Western Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-J02-HistoneH4-K20me2-Antibody-2-WB-2x5.jpg "Histone H4 [Dimethyl Lys20] Western Blot")
![Histone H4 [Dimethyl Lys20] ChIP](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-J02-HistoneH4-K20me2-Antibody-3-ChIP-4x3.jpg "Histone H4 [Dimethyl Lys20] ChIP")
![Histone H4 [Dimethyl Lys20] Western Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-J02-HistoneH4-K20me2-Antibody-4-WB-2x5.jpg "Histone H4 [Dimethyl Lys20] Western Blot")
![Histone H4 [Dimethyl Lys20] Dot Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-J02-HistoneH4-K20me2-Antibody-5-DB-4x3.jpg "Histone H4 [Dimethyl Lys20] Dot Blot")
Histone H4 K20me2 Antibody
Rabbit Polyclonal
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Background
When K20 is di-methylated on H4, the downstream effect is silencing of genes. This modification is also necessary and sufficient for 53BP1 binding, which is a prerequisite for DNA repair, a highly conserved mechanism. H4K20me2 is associated with hypoacetylation, and inactivation of certain genes. NSD1 and Suv420h1/2 trigger the dimethylation of K20, but only after SET8 catalyzes the mono-methylation of the same lysine, indicating a complex regulation of this modification that can so seriously affect replication and stability of genomic information. Anti-Histone H4 are ideal for researchers interested in Chromatin Modifiers, Chromatin Research, DNA Repair, DNA replication Transcription Translation and Splicing, Histones and Modified Histones, and Epigenetics research.
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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.