In normal cellular conditions, H3K36Me2 represses spurious transcription, via recruitment of a deacetylase complex, Rpd3s. However, in cancer cells, overexpression of a histone demethylation enzyme (KDM8) can lead to demethylation of H3K36Me2, which then leads to inhibition of HDAC recruitment and thus erroneous transcriptional activation. Therefore, the variable role of H3K36Me2 as an epigenetic repressor or activator seems critical in cancer research. Anti-Histone H3 are ideal for researchers interested in Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, and Epigenetics research.
Histone H3 [Dimethyl Lys36] affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic dimethylated peptide surrounding Lysine 36 of human Histone H3.2.