Serotonin Receptor 1B Antibody
Rabbit Polyclonal IgG
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Background
Anti-Serotonin Receptor 1B antibody detects rat Serotonin Receptor 1B. Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei. Anti-Serotonin Receptor 1B antibody is ideal for investigators involved in neurobiology.
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