RANKL Antibody
Mouse Monoclonal 12A668 IgG1 kappa
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Background
Anti-RANKL TRANCE CD254 detects mouse RANKL TRANCE CD254. RANKL, or Trance, is a member of tumor necrosis factor family. Trance (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and DCs. Trance binds to RANK on DCs and upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in DC survival. Trance is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. Trance deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis. Anti-RANKL TRANCE CD254 is ideal for investigators involved in apoptosis research.
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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
