Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli, including members of the TNF family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated Survivin (also referred to as apoptosis inhibitor 4 (API4) and TIAP). Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
API4 antibody, Apoptosis Inhibitor 4 antibody, Apoptosis inhibitor survivin antibody, Apoptosis inhibitor4 antibody, Baculoviral IAP repeat containing 5 antibody, Baculoviral IAP repeat containing protein 5 antibody, BIRC 5 antibody
This IgG fraction antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human Survivin protein.